<label id="xi47v"><meter id="xi47v"></meter></label>

      Stalk antibodies provide flu protection in humans: study

      Source: Xinhua| 2019-06-05 01:58:10|Editor: yan
      Video PlayerClose

      CHICAGO, June 4 (Xinhua) -- An international team of researchers is now a step closer to developing a universal flu vaccine after proving that targeting a specific area of the flu virus does protect humans.

      For the study, the researchers from the University of Michigan, the Icahn School of Medicine at Mount Sinai and other institutions looked at naturally occurring influenza cases in a cohort investigators have followed in Nicaragua for years.

      After one member in a household was determined to have the flu, the researchers took blood samples to test the rest of the household. They looked at who was infected with the virus antibodies and who got sick.

      Traditionally, an antibody concentration of 1:40, measured in the hemagglutination inhibition assay, has been used as a 50-percent correlate of protection from clinical disease, which means that half of the people who have those levels will be protected from influenza.

      In the study, the researchers found a similar protection, corroborating the idea that the field study design is sound to examine correlates of protection. They also found that a rise of four times in the amount of stalk antibody levels correlated with 42-percent reduction in influenza infection.

      "We were able to show that stalk antibodies do correlate with protection," said Aubree Gordon, a professor of epidemiology at UM's School of Public Health. "That is great news as it supports the idea that stalk antibodies may be able to provide protection against influenza and could enable scientists to design a broader, more effective influenza vaccine."

      The flu virus is covered with two types of proteins: hemagglutinin and neuraminidase. The current flu vaccine targets the head of the hemagglutinin, a lollipop-like structure, which is the part that changes most often. If they target the stem of the hemagglutinin, instead of the head, it would allow them to prevent a wider range of flu viruses, as these do not change as often.

      "Our research is the first to demonstrate that scientists are right in attempting to develop antibodies that target this specific location as a novel universal influenza virus vaccine candidate," Gordon said.

      The study also showed new tests can be used in flu research.

      "An additional finding of this study is that ELISA based readouts can be used as independent correlate of protection," said Florian Krammer, a professor of microbiology at the Icahn School of Medicine at Mount Sinai. "ELISAs are binding assays and do not indicate functionality, but are much easier and quicker than functional assays."

      "While there are caveats and further studies needed, this is good news for the development of stalk-based universal influenza virus vaccines," Krammer said. "It seems we are on the right track."

      The study has been published in the June issue of Nature Medicine.

      TOP STORIES
      EDITOR’S CHOICE
      MOST VIEWED
      EXPLORE XINHUANET
      010020070750000000000000011105521381168111
      主站蜘蛛池模板: 国产乱码免费卡1卡二卡3卡| 青青免费在线视频| 日本在线免费播放| 国产日产亚洲系列最新| 一区二区三区免费在线视频 | 亚洲视频一区调教| 三级网站在线免费观看| 亚洲AV综合色区无码另类小说| 三根一起会坏掉的好痛免费三级全黄的视频在线观看 | 亚洲网站免费观看| 免费在线观看h片| 亚洲一级片在线观看| 国产在线jyzzjyzz免费麻豆| 亚洲国产品综合人成综合网站| 亚洲一级毛片免费在线观看| 亚洲图片校园春色| 国产三级在线观看免费| 无码人妻AV免费一区二区三区| 中文字幕av无码无卡免费| 亚洲人成免费网站| 成人免费网站在线观看| 欧美亚洲精品一区二区| 日韩免费无码视频一区二区三区| 久久亚洲国产精品五月天| 牛牛在线精品观看免费正| 亚洲AV永久无码精品一区二区国产| 成人精品综合免费视频| 国产亚洲精久久久久久无码| 99热在线免费观看| 亚洲欧美日韩综合久久久久| 日韩精品亚洲专区在线观看| a毛片全部播放免费视频完整18| 久久精品国产精品亚洲蜜月| 一个人免费高清在线观看| 免费一区二区无码视频在线播放| 亚洲熟妇丰满多毛XXXX| 国产精品黄页免费高清在线观看| 久久久久亚洲AV片无码| 蜜桃视频在线观看免费网址入口| 特级毛片爽www免费版| 久久亚洲AV无码精品色午夜麻豆|