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      Chinese scientists develop early diagnosis of liver cancer for hepatitis B carriers

      Source: Xinhua| 2019-03-12 19:33:25|Editor: ZX
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      BEIJING, March 12 (Xinhua) -- Chinese scientists have designed a new screening method for hepatitis B carriers, to detect early-stage hepatocellular carcinoma (HCC), the most common type of primary liver cancer.

      The new method was developed by researchers from Cancer Hospital, Chinese Academy of Medical Sciences and Genetron Health, a biomedical company. Through a liquid biopsy that detects cell-free DNA somatic mutations in combination with protein markers, researchers can efficiently identify early-stage HCC cases of less than 3 cm.

      According to Yan Hai, one of the researchers, the method showed 100 percent sensitivity, 94 percent specificity and 17 percent positive predictive value in the validation cohort, proving it a feasible approach to identify early stage HCC.

      The research team will optimize this screening method through systematic research in a multi-center, large prospective cohort study, Yan said.

      After rigorous clinical validation, this method is expected to become a more convenient, non-invasive and standardized early screening program for liver cancer.

      The research was published in the U.S. journal Proceedings of the National Academy of Sciences.

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